The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains.

نویسندگان

  • Duncan Hay
  • Oleg Fedorov
  • Panagis Filippakopoulos
  • Sarah Martin
  • Martin Philpott
  • Sarah Picaud
  • David S Hewings
  • Sagar Uttakar
  • Tom D Heightman
  • Stuart J Conway
  • Stefan Knapp
  • Paul E Brennan
چکیده

Simple 1-substituted 5- and 6-isoxazolyl-benzimidazoles have been shown to be potent inhibitors of the BET bromodomains with selectivity over the related bromodomain of CBP. The reported inhibitors were prepared from simple starting materials in two steps followed by separation of the regioisomers or regioselectively in three steps.

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عنوان ژورنال:
  • MedChemComm

دوره 4 1  شماره 

صفحات  -

تاریخ انتشار 2013